Four Cheese Manicotti with Meat Sauce


Four Cheese Manicotti is a wonderful dish to make for company or even to make ahead and reheat for later. A blend of four types of cheese is stuffed in large manicotti shells and baked with a rich meat sauce. Enjoy this classic Italian dish anytime.

Four Cheese Manicotti with meat sauce topped with cheese in a baking dish

Some dishes just ooze comfort, and one of them is homemade four cheese manicotti. This recipe is perfect for a weekend, or a special dinner with family. What makes this recipe unique is a flavorful sauce that is slow-cooked to perfection before this classic dish is baked in the oven.

Flavorful Sauce Is The Key

What makes a really good pasta dish? It is the sauce. This sauce will need to simmer slowly on the stove. While it does the flavors will marry, and you will have some of the best cheese manicotti you have ever tasted. This recipe is unique because in addition to tomatoes, you will also add dry Sherry and vodka to the sauce. The sauce is so good you will want to make the sauce again and again.

Cheese Manicotti Filling

What makes this cheese manicotti so special is the variety of cheese in this dish. Parmesan, Mozzarella, Ricotta, and Italian Blend cheese all make a wonderfully balanced dish that is not to be forgotten.

Variations on this recipe

In addition to stuffing the shells full of cheese, you could swap out half of the Italian blend cheese for Fontina. You may also want to consider spicing up the sauce with a small touch of red pepper flakes if you like your sauce spicy.

Make Ahead and Reheat Later

Want to make this ahead of time, and thaw out later? Simply make the manicotti, wrap the pan with plenty of foil and plastic wrap. When you are ready to heat it up, it will take about 1 hour at 350 degrees for you to enjoy.

Four cheese manicotti with meat sauce in a baking dish

Want more Italian Inspired recipes? Check out these can’t miss recipes

Italian Style Stuffed Bell Peppers
Homemade Italian Dressing
Buca di Beppo Chicken Marsala
Homemade Italian Sausage

Four Cheese Manicotti with meat sauce topped with cheese in a baking dish

Four-Cheese Manicotti

A cheesy and meaty hearty pasta dish perfect anytime.

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Course: Main Course

Cuisine: Italian

Keyword: Cheese Recipes

Servings: 8

Calories: 808kcal


  • 30 ounces tomato puree
  • 15 ounces crushed tomatoes
  • 15 ounces tomato paste
  • 2 teaspoons chopped garlic
  • 1/2 chopped onion
  • 1 1/2 tablespoons Italian seasoning
  • 1/2 teaspoon Tabasco sauce
  • 1 cup red wine cooking sherry
  • 1/2 cup vodka
  • 2 teaspoons Sea Salt
  • 1/4 cup sugar
  • 2 pounds ground beef
  • 1 standard manicotti cooked per directions on package
  • 15 ounces Ricotta cheese
  • 1 egg
  • 1 cup grated Parmesan cheese
  • 2 cups finely shredded Italian cheese blend
  • 2 cups Mozzarella cheese


  • In large saucepan or stockpot, mix tomato puree, crushed tomatoes and tomato paste. Add chopped garlic, chopped onion, Italian seasoning, Tabasco Sauce, cooking sherry, vodka, and sea salt. Mix thoroughly. 

  • Allow sauce to cook for approximately 1 hour and then taste. If desired, add some or all of the sugar (sugar reduces the “tang” of the tomatoes). Continue cooking sauce on low heat for several more hours (ideally and for a richer blend of the seasonings, sauce should be refrigerated overnight and cooked for an additional 2-3 hours the following day for optimal flavor). 

  • Thoroughly cook ground beef and drain (rinse with water if necessary to remove all grease). Return to pan and season with a few shakes each of salt, pepper, garlic and onion powder, and cook for an additional 10 minutes.

  • Remove and add meat to the sauce. Cook pasta according to the package directions, drain and allow to cool, separately, on wax paper. In a separate mixing bowl, blend ricotta cheese, egg, grated parmesan, and the shredded Italian cheese blend until thoroughly mixed. Using the butter knife, begin to stuff the manicotti shells with cheese mixture until all is used. In a large baking pan (a lasagna pan is best), spread a layer of sauce that completely covers the bottom of the pan.

  • Align the stuffed manicotti shells in the pan atop the sauce. Use remaining sauce to completely cover the pasta. Use as much or as little as desired of the mozzarella shredded cheese to cover. Bake in a 350-degree oven until cheese bubbles and begins to turn a golden brown. Remove, cool, and serve.


Calories: 808kcal | Carbohydrates: 35g | Protein: 49g | Fat: 47g | Saturated Fat: 20g | Cholesterol: 166mg | Sodium: 2820mg | Potassium: 1627mg | Fiber: 5g | Sugar: 21g | Vitamin A: 2045IU | Vitamin C: 28.7mg | Calcium: 546mg | Iron: 7.4mg

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